Main Research: Neurosciences

Term: 16.11.2020 – 15.05.2023

sALS is a motor neuron disease where pathological insoluble states of TDP-43, an alternative splicing (AS) factor are found. Dysregulated AS is detected, but it is unknown whether TDP-43 aggregation is causative for this. We develped an iPSC-derived model of sALS where AS changes in this system are not dependent on TDP-43. We propose to investigate pathological mechanisms of new AS factors in sALS using proteomics and NGS approaches and subsequent validation in sALS post mortem tissue.

Principal Investigator
Dr. Florian Krach