Oncology
J96: Maria de los Reyes Gamez Belmonte, Department of Medicine 1
Bace1/Bace2 in colorectal cancer development
Main Research: Oncology
Term: 01.10.2021 – 31.03.2024
The B-secretases (Bace1 and Bace2) are proteases involved in the pathogenesis of Alzheimer’s disease (AD). However, Bace1/2 can be found in tissues other than the brain, suggesting that their role goes well beyond AD. Interestingly, our preliminary data reveal that the expression of Bace1/2 is modulated in response to intestinal inflammation and during cancer development. We hypothesize that the B-secretases might have regulatory functions in the gut and the pathophysiology of colorectal cancer.
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| Principal Investigator Dr. Maria de los Reyes Gamez Belmonte Phone: +49 9131 85-35909 Email: MariadelosReyes.GamezBelmonte@uk-erlangen.de |
J97: Benedikt Jacobs, Department of Medicine 5
Immune-metabolic dysfunction of NK cells
Main Research: Oncology
Term: 01.01.2022 – 30.06.2024
The metabolism of reconstituting NK cells upon autologous SCT is altered in lymphoma patients who experience an early relapse upon transplantation. We intend to decipher the underlying cellular and molecular mechanism to identify factors leading to the increased relapse risk and to reveal potential opportunities to modify them. This will lay the foundation for further projects investigating NK cell reconstitution upon allogeneic SCT and CAR-transfected NK cell expansion in tumor patients.
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| Principal Investigator Dr. Benedikt Jacobs Phone: +49 9131 85-43210 Email: Benedikt.Jacobs@uk-erlangen.de |