• Jump to content
  • Jump to navigation
  • Jump to bottom of page
Simulate organization breadcrumb open Simulate organization breadcrumb close
Interdisciplinary Center for Clinical Research
  • FAUTo the central FAU website
  1. Friedrich-Alexander-Universität
  2. Faculty of Medicine
  • en
  • de
  • Universitätsklinikum
  • Life@FAU
  • IZKF-Tool
  • ELAN-Tool
  1. Friedrich-Alexander-Universität
  2. Faculty of Medicine

Interdisciplinary Center for Clinical Research

Navigation Navigation close
  • IZKF
    • Structure
    • Committees
    • IZKF Administrative Office
    • Other IZKF
    • IZKF publications
    Portal IZKF Erlangen
  • Advanced projects
    • Programme
    • Application Procedure
    • Current projects
    • Project Handling
    Portal Advanced projects
  • Juniors
    • Jochen-Kalden-Funding Programme
    • Junior Projects
    • Clinician Scientist Programme
    • Laboratory Rotations
    • MD-Thesis Scholarships
    • IZKF Research Training Group
    • IZKF Publication Award for Young Scientists
    Portal Juniors
  • ELAN
    • Programme
    • Application Procedure
    • Current projects
    • Project Handling
    Portal ELAN
  • Central projects
    • Special Programmes
    • Visiting Professor Programme
    • Bridging Projects
    • IZKF-Symposium
    Portal Central projects
  1. Home
  2. Juniors
  3. Junior Projects
  4. Current Projects
  5. Oncology

Oncology

In page navigation: Juniors
  • Jochen-Kalden-Funding Programme
    • Application procedure
    • N2 Physics and Medicine (Dulin)
    • N5 Organ crosstalks in IMIDs (Günther)
    • N6 Rare glomerular diseases (Müller-Deile)
    • N7 Forging neural cell identity (Karow)
    • N8 Lysosomal dysfunction in glia (Zunke)
    • Archive Junior Research Groups
      • Junior Research Group 1, Dr. Ceppi
      • Junior Research Group 2, Prof. Titze
      • Junior Research Group 3, Prof. Winner
  • Junior Projects
    • Application Procedure
      • Call for proposals: Junior Projects 2022
    • Current Projects
      • Infection and Immunology
      • Oncology
      • Neurosciences
      • Renal and Vascular Research
      • Further projects
      • Archive Junior Projects
    • Project Handling
  • Clinician Scientist Programme
    • Application procedure
      • Admission into the Clinician Scientist Programme
    • Participants
    • Alumni
  • Laboratory Rotations
    • Application procedure
    • Current Laboratory Rotations
    • Project Handling
  • MD-Thesis Scholarships
    • Application procedure
    • Current Scholarhip Holders
      • Archive MD-Thesis Scholarships
  • IZKF Research Training Group
    • Application procedure
    • Events
      • Guest speaker seminars
      • Jour Fixe
      • Seminars
      • IZKF Postgraduate Workshop
        • IZKF Postgraduate Workshop 2018
      • IZKF-Retreat
        • IZKF-Retreat 2018
  • IZKF Publication Award for Young Scientists
    • Announcement Publication Award for Young Scientists 2022

Oncology

J67: Regina Jitschin, Department of Medicine 5
Metabolic reprogramming of AML MDSCs

Main Research: Oncology

Term: 01.01.2018 – 30.06.2021

AML is the most common acute leukemia in adults. Emerging evidence suggests that immune alterations favor leukemogenesis and relapse. Myeloid derived suppressor cells (MDSCs) are mediators of tumor immune escape. Here, we aim to decipher the interconnection between metabolic reprogramming and MDSC abundance in AML and to unravel the role of AML-derived exosomes in this context. A better understanding is key for improving immune-based therapeutic approaches in AML

Principal Investigator
Dr. Regina Jitschin
phone: +49 9131 85-43113
e-mail: regina.jitschin@uk-erlangen.de

J96: Maria de los Reyes Gamez Belmonte, Department of Medicine 1
Bace1/Bace2 in colorectal cancer development

Main Research: Oncology

Term: 01.10.2021 – 31.03.2024

The B-secretases (Bace1 and Bace2) are proteases involved in the pathogenesis of Alzheimer’s disease (AD). However, Bace1/2 can be found in tissues other than the brain, suggesting that their role goes well beyond AD. Interestingly, our preliminary data reveal that the expression of Bace1/2 is modulated in response to intestinal inflammation and during cancer development. We hypothesize that the B-secretases might have regulatory functions in the gut and the pathophysiology of colorectal cancer.

Principal Investigator
Dr. Maria de los Reyes Gamez Belmonte
Phone: +49 9131 85-35909
Email: MariadelosReyes.GamezBelmonte@uk-erlangen.de

J97: Benedikt Jacobs, Department of Medicine 5
Immune-metabolic dysfunction of NK cells

Main Research: Oncology

Term: 01.01.2022 – 30.06.2024

The metabolism of reconstituting NK cells upon autologous SCT is altered in lymphoma patients who experience an early relapse upon transplantation. We intend to decipher the underlying cellular and molecular mechanism to identify factors leading to the increased relapse risk and to reveal potential opportunities to modify them. This will lay the foundation for further projects investigating NK cell reconstitution upon allogeneic SCT and CAR-transfected NK cell expansion in tumor patients.

Principal Investigator
Dr. Benedikt Jacobs
Phone: +49 9131 85-43210
Email: Benedikt.Jacobs@uk-erlangen.de
Universitätsklinikum Erlangen
IZKF Administrative Office

Krankenhausstr. 12
91054 Erlangen
  • Download-Center
  • Events
  • Contact
  • Imprint
  • Privacy
Up