Renal and Vascular Research
Main Research: Renal and Vascular Research
Term: 01.10.2018 – 31.03.2021 (bonus time until 30.09.2021)
The genetic background of chronic kidney disease in adults in poorly investigated. This study aims to identify novel candidate genes by Whole Exome Sequencing in adult patients with chronic kidney disease. Transcriptome analysis of patient specific primary cells will be employed to functionally characterize these candidate genes. CRISPR/Cas9 based zebrafish experiments will transfer the in vitro findings in an animal disease model.
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| Principal Investigator Dr. Tilman Jobst-Schwan e-mail: tilman.jobst-schwan@uk-erlangen.de |
Main Research: Renal and Vascular Research
Term: 01.01.2019 – 30.06.2021
The aim of our project is to descramble the role of the purinergic receptor P2Y2R in the context of Ca2+-dependent Cl–secretion as a main course of cyst growth in ADPKD. We will use our novel PKD1-deficient 3D cyst model and micropuncture cysts to analyse the effects of luminal ATP as well as the P2 inhibitor Suramin. In addition, we will test for the impact of P2Y2R knockout on the cystic burden in our PKD1 knockout mouse model and determine the therapeutic potential of Suramin in vivo.
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| Principal Investigator Dr. Andre Kraus phone: +49 9131 85-40110 e-mail: andre.kraus@uk-erlangen.de |