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Neuroscience

Orofacial clefts are frequent congenital malformations. Etiology is complex, poorly understood and involves environmental and genetic factors. We could identify several cranial neural crest transcription factors and chromatin remodelers as key regulators of palatal development. We will use genome-edited cell lines and mouse mutants to determine the exact function and relationship of these factors in their regulatory network and thus better understand palatal development and orofacial clefting.

Principal Investigator
Prof. Dr. Lina Gölz
Phone: +49 9131 85-33643
E-Mail: lina.goelz@uk-erlangen.de
Principal Investigator
Prof. Dr. Michael Wegner
Phone: +49 9131 85-24620
E-Mail: michael.wegner@fau.de

Recent data indicates that adult neural stem cell dysfunction and the resulting impairment of adult hippocampal neurogenesis contributes to cognitive deficits in human ageing and neurodegenerative diseases. The mechanisms underlying ageing-associated neural stem cell dysfunction are largely unknown. This project will investigate the hypothesis that dysfunction of lysosome-dependent degradation pathways is a major contributor for hippocampal neural stem cell dysfunction during ageing.

Principal Investigator
Prof. Dr. Dieter Chichung Lie
Phone: +49 9131 85-24622
E-Mail: chi.lie@fau.de

Term: 01.04.2020 – 30.09.2022

Recent data demonstrate profound immunological alterations in Parkinson’s disease (PD). We study the contribution of the peripheral immune system to onset and progression in PD. Specifically, we perform a comprehensive characterization of peripheral immunity in early vs. late onset with rapid vs. slow disease progression PD patients. Subsequently, we will determine neurotoxicity in human autologous co-cultures of stem cell-derived midbrain neurons and specific immune cells.

Principal Investigator
Prof. Dr. Beate Winner
Phone: +49 9131 85-39301
E-Mail: beate.winner@uk-erlangen.de
Principal Investigator
Prof. Dr. Jürgen Winkler
Phone: +49 9131 85-39323
E-Mail: juergen.winkler@uk-erlangen.de

Term: 01.01.202020 – 30.06.2022

Neurodevelopmental disorders (NDDs) are extremely heterogeneous but converge on a number of common molecular processes. Treatment options are limited so far. We will focus on a subset of NDD associated genes/proteins which are involved in the ubiquitin-proteasome system. We will investigate if manipulation of proteasome activity by small molecules can ameliorate phenotypes in Drosophila and/or cell based model systems and thus will gain insights into potential interventional options.

Principal Investigator
Prof. Dr. Christiane Zweier
phone: +49 9131 85-29113
email: christiane.zweier@uk-erlangen.de